The 1968–69 season of the European Cup football club tournament was won by Milan, who beat Ajax 4–1 in the final, giving Milan its first European Cup title since 1963, and its second overall. A number of Eastern European clubs withdrew from the first two rounds when UEFA paired up all of the Eastern European clubs against one another.
The Golden era of Spartak began in the season of 1966/67. The team of legendary coach Anton Malatinský was top of the league by autumn, but by the end of the season had only finished in third place. Great success was achieved in the Mitropa Cup. Spartak beat teams like Budapest Honvéd FC, S.S. Lazio and ACF Fiorentina and in final the defeated Újpest FC of Hungary. In the following season Spartak gained their memorable first title. They reached the semi-final of European Cup to face Ajax Amsterdam. It is their greatest success up until now. Under the management of Ján Hucko, the team also won a second championship. In 1970/71 and 1971/72, Trnava won their third and fourth championship titles under coaches Valér Švec and Anton Malatinský. The team also reached the quarter-final of European Cup in 1973 and 1974. The fifth and the last league title in 1972/73 beckoned the end of Spartak's golden era.